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The approval is based on Phase III MATTERHORN trial data showing improvements in event-free survival (EFS) and overall survival (OS).
November 26, 2025
By: Charlie Sternberg
Associate Editor
AstraZeneca’s IMFINZI (durvalumab) in combination with standard-of-care FLOT chemotherapy (fluorouracil, leucovorin, oxaliplatin, and docetaxel) has been approved in the U.S. for the treatment of adult patients with resectable, early-stage and locally advanced (Stages II, III, IVA) gastric and gastroesophageal junction (GEJ) cancers. The approved regimen includes neoadjuvant IMFINZI in combination with chemotherapy before surgery, followed by adjuvant IMFINZI in combination with chemotherapy, th...
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